Angela Garcia, Caleb Finch, Margaret Gatz, Thomas S. Kraft, Daniel Eid Rodriguez, Daniel Cummings, Mia Charifson, Kenneth Buetow, Bret A. Beheim, Hooman Allayee, Gregory Thomas, Jonathan Stieglitz, Michael Gurven, Hillard Kaplan, and Benjamin C. Trumble
n. 10:e68231, September 2021, 20 pages
In post-industrial settings, apolipoprotein E4 (APOE4) is associated with increased cardiovascular and neurological disease risk. However, the majority of human evolutionary history occurred in environments with higher pathogenic diversity and low cardiovascular risk. We hypothesize that in high-...